I AM BLOGGING AT LJ????!!
Haha for fun, nothing much.

 and im sorry.

i've got a new door knob(:
sadly it's gold though silver will look nicer
but at least i got a working door now.

and all i did so far was integration tutorial 8, 3/4 of polar asg 3 and ONE question of bio lab. 
oh and i found an article for bio asg.
in other words, i havent done a lot today.
ahh so much for waking up earlier to attempt to do homework.
but tv in the morning was nice(:
i love martial arts shows.

HOMEWORK ):
1. polar asg 3, by 16/10
2. polar journal, by 16/10
3. integration tutorial 8, by 8/10
4. integration asg 8, by ?
5. chem tutorial 3 (and 4?), by 9/10
6. bio lab report, by 9/10
7. bio asg 2, by 17/10
8. bio project, by 24/10
9. chinese o level book (until 12th paper), by 8/10

TESTS/QUIZZES ):
1. integration quiz on 8/10
2. math test on 10/10
3. physics test on 17/10


): so many things to do. 

sometimes i dont understand how people can be so selfish, unwilling to contribute to work the fields yet so eager when the harvest is perfect. 
it's not the way to have the intentioni of burning holes out of peoples' pockets, especially when those are nice people who willingly agree to give you that little advantage. 

i wanted to write more, but i shant, back to the "i shall keep those to myself" line.

thursday. 
i messed up em spec quiz a little, by writing 6 instead of 5.
ahwells, i hope i get a grade good enough to pull my other quiz up.

friday tomorrow(: end of the week yayy. 
then sat and sun can watch more tv.
the last breakthrough is <3

im like tired!
ahhh
math bio chem bio math
that was what i had today.
like some palindromic number sequence. haha

yeah but anyway, im seriously scared to eat the food in the schoool canteen cos it gives me stomachaches!
ahhhhh

[dinner brb] 


ARGH im very very sure i blogged after dinner just now, and i saw it being posted!
but now it's gone! 
yikkkkes.
okay maybe i clicked on the wrong icon.
dreads.
okay im not gonna say what i said just now (cos i forgot what it was about already)
but anyway, i realise that sometimes people have a very very wrong perception of competitions and im sure i myself used to think so too. basically some people just think the idea of competitions is just winning, to win and to tell everyone you've won. i dont like that mentality. but im pretty sure i used to think competitions are there for you to win and that if you dont win you should go bury yourself underground.
i guess i no longer think that way (or most of the time i dont). but rather that i dont wanna care if i win or not, but instead i just want to do it because i want to gain more experience or because im interested or plainly for fun. im not saying that we should all do something just cos it's fun, but i seriously dont think theres a need to only show off when you win. or worse still publicise your winning of a competition that is not very significant. i dont think im getting much stuff across, because im not going name anything here. im sorry if i wasted your time reading hahah.


 

i really think that if you want someone to do what you say, then you yourself will have to set an example for people to follow. like if teachers want their students to come to class on time, then the teachers themselves shouldnt be late. or when they want their students to not plagiarise, i think they themselves shouldnt do it. i guess thats pretty much a reason why i kind of think mr ng makes an effective teacher and i guess many should share the same sentiments. like how he makes sure he's in the class way earlier than the actual start time so that he can put pressure on us to rush to class and make sure we're not late. or mrs loh. well, for now, i can say i pretty much enjoy physics. and i guess i get really affected if teachers dont show interest in what they are teaching. i guess at the very least i can see that mrs loh is pretty much enthusiastic about what she's teaching which is a good thing. i dont think im gonna carry on cos i need to go for dinner. but basically, i detest people who dont set a standard for others to follow especially when they themselves fall way below the standard that they want others to attain. 

------
and ive decided to return back here for one reason. BIO
):

GENOME ORGANIZATION AND GENE REGULATION

1. Chromatin structure and DNA packaging
- Chromatin structure based on successive levels of DNA packing
- 1st layer:
  > proteins (called histones) are highly positive
  > bind tightly to the negatively charge DNA
  > chromatins have appearance of beads on a string
  > each "bead"= a nuclesome, the basic unit of DNA packing
  > "string" which links up the beads= linker DNA
  > nucleosome consists of DNA wound around protein core which consists of 2 molecules of histone (4
     types available= H2A, H2, H3, H4)
  > amino end of each histone protein (histone tail) extends outward from nucleosome
  > 5th histone (H1) attaches to DNA near nucleosome when chromatin fiber undergoes next level of   
     packing
- Higher levels:
  > due to interactions between histone tails on nucleosome and the link DNA and the nucleosomes to
     either side
  > fiber coils/fold to form a thicker chromatin fiber which forms loops (looped domains) attached to a 
     chromosome scaffold made of non-histone proteins
  > in mitotic chromosome, looped domains coil and fold, further compacting all the chromatin
- heterochromatin: chromatin with irregular clumps and is highly compact. is largely inaccessable to 
  transcription enzymes
- euchromatin: true chromatin, less compacted. DNA is accessible to enzymes and available for
  transcription

2. Gene expression
- regulated at any stage, key step= transcription
- differential gene expression:
  > each cell espressses only a fraction of genes
  > key stages for gene expression here= chromatin structure changes, initiation of transcription, RNA
     processing, mRNA degration, translation, protein processing and degradation
- regulation of chromatin structure:
  > genes in highly compacted chromatin are not transcribed
  > chemical modification of histone tails can afect configuration of chromatin and gene expression
  > histone acetylation loosens structure, enhances transcription
  > DNA methylation associated with reduced transcription
- transcription initiation:
  > multiple DNA control elements distant from promoter bind specific transcription factors
  > regulate transcription initiation for specific genes within genome
  > bending of DNA enables activators bound to enhancers contact proteins at promoter
  > coordinately controlled eukaryotic genes have promoter and control elements unlike prokaryotic operon
  > same regulatory sequences common to all genes of a group
  > enables recognition by same specific transcription factors
- post- transcriptional regulation
  > regulation at RNA-processing level exemplified by alternative RNA splicing
  > each mRNA has characteristic life span, determined by sequences in the leaderand trailer regions
  > RNA interference by single-stranded micro-RNAs lead to degradation of mRNA or block its translation
  > initiation of translation controlled via regulation of initiation factors
  > after translation, various types of protein processing subject to control, like degradation of proteins by 
     proteasomes

3. Cancer
- genes associated with cancer:
  > proto-oncogenes and tumor-suppressor genes control cell division
  > DNA change that makes a proto-oncogene excessively active converts it to an oncogene which may
     promote excessive cell division and cancer
  > tumor-suppressor gene encodes a protein that inhibits abnormal cell division
  > nutation in such a gene reduces activity of its protein product
  > may lead to excessive cell division and possibly cancer
- interference with normal cell-signalling pathways:
  > many proto-oncogene and tumor-suppressor genes encode components of growth-stimulating and 
     growth-inhibiting signaling pathways respectively
  > hyperactive protein in stimulatory pathway (e.g Ras, a G protein) may function as an oncogene  
     (excessive cell division)
  > defective protein in an inhibitory pathway (e.g p53) fails to function as a tumor suppressor
- multistep model of cancer development:
  > normal cells converted to cancer cells by accumulation of multiple mutations affecting proto-oncogenes
     and tumor-suppressor genes
  > certain viruses promote cancer by integration of viral DNA into a cell's genome
- inherited predisposition to cancer:
  > individuals who inherit a mutant oncogene or tunor-supressor allele have increased risk of developing
     certain cancer types.

4. non-coding DNA sequences
- transposable elements:
  > transposons move via a DNA intermediate
  > retrotransposons are most prevalent and move via a RNA intermediate
  > movement or recombination between copies of the same element occasionally generates new
     sequence combinations that are beneficial
  > can alter functions of genes or patterns of expression and regulation
- other repetitive DNA:
  > short noncoding sequences are repeated many times 
  > especially prominent in centromeres and telomeres, where they probably play structural roles in
     the chromosome
- genes and multigenes:
  > most eukaryotic genes present in one copy per haploid set of chromosomes
  > transcription unit encoding the three largest rRNAs repeated many times at one/several chromosomal 
     sites
  > enables cell to make the rRNA for millions of ribosomes quickly
  > multiple, slightly different genes in the two globin gene families encode polypeptides used at different
     developmental stages of an animal

5. duplication
- duplication to chromosome sets:
  > accidents in cell division can lead to extra copies of all or part of a genome
  > may diverge if one set accumulates sequence changes
- duplication and divergence of DNA segments
  > genes encoding various globin proteins evolved from one common ancestral globin gene which
     duplicated and diverged into alpha-globin and beta-globin ancestral genes
  > subsequent duplications of these genes plus random mutations gave rise to present globin genes
  > all of which code for oxygen-binding proteins
  > copies of some duplicated genes have diverged so much during evolutionary time that functions of their
     encoded proteins are substantially different

6. rearrangements
- exon duplication and exon shuffling
  > rearrangement of exons within and between genes during evolution led to gene containing multiple 
     copies of similar exons
  > and/or several different exons derived from other genes
 

watching 我爱星期天now, cos have wushu stuff in it today.
omggg. i loved that whole wushu demo stuff.
and that little boy is like PRO.
well, better than i am was. 
ahwells. that whole routine was SO familar.
wu duan chang quan. 
<3
then i think the girl did the old competition chang quan routine, i.e. the one i screwed up during nationals last last year.):
ahwells. miss wushu): ):